Issue 3, 2023

Steroidal alkaloid with unprecedented triheterocyclic architecture

Abstract

Veratrazine A (1), a steroidal alkaloid with a unique 6/5/5 triheterocyclic scaffold as the side chain, was isolated from Veratrum stenophyllum, and its structure was established via spectroscopic analyses and X-ray diffraction. A plausible biosynthetic pathway for 1 is proposed. Bioassy exhibits moderate anti-inflammatory activities in vitro and in vivo.

Graphical abstract: Steroidal alkaloid with unprecedented triheterocyclic architecture

Supplementary files

Article information

Article type
Communication
Submitted
15 Nov 2022
Accepted
05 Dec 2022
First published
13 Dec 2022

Chem. Commun., 2023,59, 326-329

Steroidal alkaloid with unprecedented triheterocyclic architecture

Z. Zhou, Y. Zhao, B. Hu, B. Wang, Y. Liu, Y. Zhu, Y. He, Z. Wang, Z. Dai, L. Zhao and X. Luo, Chem. Commun., 2023, 59, 326 DOI: 10.1039/D2CC06073F

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