Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

Hong Liang; Zhike Yan; Yuhong Tong; Shan Chen; Jingying Li; Lanlan Chen; Huanghao Yang

doi:10.1039/D2CC06176G

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Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo†

Hong Liang,

^a Zhike Yan,^b Yuhong Tong,^b Shan Chen,

^a Jingying Li,

^c Lanlan Chen

*^b and Huanghao Yang

*^b

Author affiliations

* Corresponding authors

^a College of Geography and Oceanography, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou 350108, People's Republic of China

^b MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China
E-mail: llchen@fzu.edu.cn, hhyang@fzu.edu.cn

^c College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, People's Republic of China

Abstract

We developed a circular bivalent aptamer (CBA) to precisely activate membrane receptor-mediated regenerative signaling for liver repair in vivo. The CBA showed enhanced biostability and receptor binding avidity, achieving effective pathway activation and satisfactory treatment in an acetaminophen-induced liver injury model. This work expands aptamer-based molecular engineering in regenerative medicine.

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Article information

DOI: https://doi.org/10.1039/D2CC06176G
Article type: Communication
Submitted: 19 Nov 2022
Accepted: 11 Jan 2023
First published: 12 Jan 2023

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Chem. Commun., 2023,59, 1621-1624

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Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

H. Liang, Z. Yan, Y. Tong, S. Chen, J. Li, L. Chen and H. Yang, Chem. Commun., 2023, 59, 1621 DOI: 10.1039/D2CC06176G

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Chemical Communications

Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo†

Abstract

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Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

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