Issue 14, 2023

A phototoxic thulium complex exhibiting intracellular ROS production upon 630 nm excitation in cancer cells

Abstract

A lanthanide(III) complex with a thulium metal centre connected via a terpyridine unit to a light harvesting antenna with strong absorption in the therapeutic window [>590 nm] was synthesised and tested as a possible photosensitiser (PS) in photodynamic therapy (PDT). The complex exhibited significant phototoxic activity on cancer cells upon irradiation in the therapeutic window and from intracellular and solution studies ROS production was identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold lowered IC50 value was obtained upon irradiation compared to the dark control.

Graphical abstract: A phototoxic thulium complex exhibiting intracellular ROS production upon 630 nm excitation in cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
17 Nov 2022
Accepted
12 Jan 2023
First published
19 Jan 2023

Chem. Commun., 2023,59, 1943-1946

A phototoxic thulium complex exhibiting intracellular ROS production upon 630 nm excitation in cancer cells

D. Obitz, K. S. Gkika, M. Heller, T. E. Keyes and N. Metzler-Nolte, Chem. Commun., 2023, 59, 1943 DOI: 10.1039/D2CC06209G

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