Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching

Tingting Zheng; Jielin Fu; Qin Xiong; Xin Shen; Baolin Li; Xiaohu Zhao; Zhipeng Yu

doi:10.1039/D2CC06738B

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Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching†

Tingting Zheng,^a Jielin Fu,^a Qin Xiong,^a Xin Shen,^a Baolin Li,^a Xiaohu Zhao^a and Zhipeng Yu

*^a

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* Corresponding authors

^a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China
E-mail: zhipengy@scu.edu.cn

Abstract

We report two evolved Methanosarcina mazei pyrrolysine tRNA synthetases to genetically incorporate the isomers of dibenzo[c,g][1,2]diazocine-alanine (DBDAA) into proteins either in the dark or under regulation of 405 nm photo-stimulation. The genetic-encoded DBDAA realizes photo-tuning of enzymatic activity via the host–guest recognition of cucurbit[7]uril.

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DOI: https://doi.org/10.1039/D2CC06738B
Article type: Communication
Submitted: 10 Dec 2022
Accepted: 03 Jan 2023
First published: 03 Jan 2023

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Chem. Commun., 2023,59, 1201-1204

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Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching

T. Zheng, J. Fu, Q. Xiong, X. Shen, B. Li, X. Zhao and Z. Yu, Chem. Commun., 2023, 59, 1201 DOI: 10.1039/D2CC06738B

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Chemical Communications

Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching†

Abstract

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Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching

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