Issue 27, 2023
From the journal:

Chemical Communications

Silver cluster-assembled materials for label-free DNA detection†

Saikat Das,a   Taishu Sekine,a   Haruna Mabuchi,a   Sakiat Hossain,a   Subhabrata Das, ORCID logo b   Shun Aoki,c   Shuntaro Takahashi ORCID logo *b  and  Yuichi Negishi ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
E-mail: negishi@rs.tus.ac.jp

b Chemical Materials Development Department, TANAKA KIKINZOKU KOGYO K.K., Tsukuba Technical Center, 22 Wadai, Tsukuba, Ibaraki 300-4247, Japan
E-mail: s-tak@ml.tanaka.co.jp

c Bio Chemical Development Department, TANAKA KIKINZOKU KOGYO K.K., Hiratsuka Technical Center, 2-73, Shinmachi, Hiratsuka, Kanagawa 254-0076, Japan

Abstract

Herein, we report two newly synthesized silver cluster-assembled materials (SCAMs), [Ag14(StBu)10(CF3COO)4(bpa)2]n (bpa = 1,2-bis(4-pyridyl)acetylene) and [Ag12(StBu)6(CF3COO)6(bpeb)3]n (bpeb = 1,4-bis(pyridin-4-ylethynyl)benzene) composed of Ag14 and Ag12 chalcogenolate cluster cores, respectively, bridged by acetylenic bispyridine linkers. The linker structures and electrostatic interaction between positively charged SCAMs and negatively charged DNA confer the SCAMs with the ability to suppress the high background fluorescence of single-stranded (ss) DNA probes with SYBR Green I nucleic acid stain, leading to high signal-to-noise ratio for label-free target DNA detection.

Graphical abstract: Silver cluster-assembled materials for label-free DNA detection

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Article information

DOI
https://doi.org/10.1039/D2CC06933D
Article type
Communication
Submitted
20 Dec 2022
Accepted
27 Feb 2023
First published
27 Feb 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 4000-4003

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Silver cluster-assembled materials for label-free DNA detection

S. Das, T. Sekine, H. Mabuchi, S. Hossain, S. Das, S. Aoki, S. Takahashi and Y. Negishi, Chem. Commun., 2023, 59, 4000 DOI: 10.1039/D2CC06933D

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