Issue 30, 2023

Three-in-one self-assembled metallo-nanophotosensitizers for photodynamic/chemodynamic/chemo multimodal synergistic cancer therapy

Abstract

A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic L-arginine-modified photosensitizer NBS-L-Arg and DOX in the presence of Cu2+via the synergy of coordination, hydrophobic, and π–π stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.

Graphical abstract: Three-in-one self-assembled metallo-nanophotosensitizers for photodynamic/chemodynamic/chemo multimodal synergistic cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
01 Feb 2023
Accepted
15 Mar 2023
First published
16 Mar 2023

Chem. Commun., 2023,59, 4479-4482

Three-in-one self-assembled metallo-nanophotosensitizers for photodynamic/chemodynamic/chemo multimodal synergistic cancer therapy

S. Chao, Z. Shen, J. Ren, Z. Zhang, X. Chen, Y. Pei and Z. Pei, Chem. Commun., 2023, 59, 4479 DOI: 10.1039/D3CC00469D

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