Accurate detection of reactive oxygen species by tuning an elastic motif (GPGGA)4 in nanopores

Abstract

We have developed a reactive oxygen species (ROS) sensor based on nanopores modified with GGGCEG(GPGGA)₄CEG. The formation of an intramolecular disulfide bond oxidized by ROS leads to conformation changes in GGGCEG(GPGGA)₄CEG, which then induces an obvious change in the size of the nanopores and a corresponding ionic current change. This work allows the accurate and dynamic monitoring of ROS through the combination of (GPGGA)₄ and nanopores.