Issue 30, 2023

Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality

Abstract

We describe herein an intriguing method for the synthesis of biaryl aldehydes bearing both axial and central chirality through a desymmetric [3 + 2] cycloaddition reaction of activated isocyanides with prochiral biaryl dialdehydes under silver catalysis. This protocol features excellent enantioselectivity, 100% atom economy, good functional group compatibility, and operational simplicity.

Graphical abstract: Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2023
Accepted
21 Mar 2023
First published
21 Mar 2023

Chem. Commun., 2023,59, 4487-4490

Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality

F. Huang, L. Tao, J. Liu, L. Qian and J. Liao, Chem. Commun., 2023, 59, 4487 DOI: 10.1039/D3CC00708A

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