A rigid-axle-based molecular rotaxane channel facilitates K+/Cl− co-transport across a lipid membrane

Shihao Pang; Xiaonan Sun; Zexin Yan; Chuantao Wang; Kai Ye; Shinan Ma; Linyong Zhu; Chunyan Bao

doi:10.1039/D3CC00811H

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A rigid-axle-based molecular rotaxane channel facilitates K⁺/Cl⁻ co-transport across a lipid membrane†

Shihao Pang,^a Xiaonan Sun,^a Zexin Yan,^a Chuantao Wang,^a Kai Ye,^a Shinan Ma,^a Linyong Zhu

^a and Chunyan Bao

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: baochunyan@ecust.edu.cn

Abstract

Inspired by the design criteria of heteroditopic receptors for ion-pair binding, we herein describe a new strategy to construct a rotaxane transporter (RR[2]) for K⁺/Cl⁻ co-transport. The use of a rigid axle improves the transport activity with an EC₅₀ value of 0.58 μM, presenting a significant step toward developing rotaxane artificial channels.

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Article information

DOI: https://doi.org/10.1039/D3CC00811H
Article type: Communication
Submitted: 21 Feb 2023
Accepted: 03 Mar 2023
First published: 06 Mar 2023

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Chem. Commun., 2023,59, 3866-3869

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A rigid-axle-based molecular rotaxane channel facilitates K⁺/Cl⁻ co-transport across a lipid membrane

S. Pang, X. Sun, Z. Yan, C. Wang, K. Ye, S. Ma, L. Zhu and C. Bao, Chem. Commun., 2023, 59, 3866 DOI: 10.1039/D3CC00811H

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