A protocol for visible-light-induced C–H acylation selectively at the C6 position of purine nucleosides with aldehydes under photocatalyst-free conditions was established herein. This protocol allows the green, mild, and efficient functionalization of various purine nucleosides with a broad range of alkyl and aryl aldehydes.
L. Li, H. Zheng, F. Guo, Z. Fang, Q. Sun, J. Li, Q. Gao, T. Zhang and L. Fang, Chem. Commun., 2023, 59, 3910 DOI: 10.1039/D3CC00906H
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