Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization

Abstract

In this study, a straightforward, moisture insensitive, and regioselective Fe^III–Cu^II/p-TSA–Cu^I catalyzed reaction is achieved from readily available isatin and 2-alkynylaniline to furnish diverse 12-benzoyl/benzyl/alkyl indolo[1,2-c]quinazolin-6(5H)-ones. This catalytic method includes C–C cleavage, multi bond forming ring expansion, fused-ring construction, broad substrate scope, gram-scale producibility, and high atom economy.