Employing a chiroptical sensor for the absolute stereochemical determination of α-amino and α-hydroxyphosphonates

Abstract

The absolute stereochemistry of the α-amino and α-hydroxyphosphonates is determined using a chiroptical sensor. The induced helicity of the host–guest complex is correlated to the chirality of the guest molecule via a simple binding model. The relative size of the substituents dictates the predominant helical population, leading to an easy circular dichroic readout.