An injectable nanocomposite alginate-Ca2+ hydrogel for melittin-assisted Ca2+-overload and photothermal cancer therapy

Wen Jing Yang; Ruixiang Ma; Shibing Wei; Wenping Sun; Wenya Xu; Lianhui Wang

doi:10.1039/D3CC01867A

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An injectable nanocomposite alginate-Ca²⁺ hydrogel for melittin-assisted Ca²⁺-overload and photothermal cancer therapy†

Wen Jing Yang,

^a Ruixiang Ma,^a Shibing Wei,^a Wenping Sun,^a Wenya Xu^a and Lianhui Wang

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Organic Electronics and Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, China
E-mail: iamlhwang@njupt.edu.cn

Abstract

An injectable nanocomposite alginate-Ca²⁺ hydrogel embedded with melittin and polyaniline nanofibers was fabricated for Ca²⁺-overload and photothermal combination cancer therapy. Melittin disrupts the cell membranes and enhances Ca²⁺ influx significantly, improving Ca²⁺-overload treatment, while the polyaniline nanofibers endow the hydrogel with glutathione (GSH) depletion and photothermal ability.

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Article information

DOI: https://doi.org/10.1039/D3CC01867A
Article type: Communication
Submitted: 16 Apr 2023
Accepted: 12 Jun 2023
First published: 20 Jun 2023

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Chem. Commun., 2023,59, 8568-8571

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An injectable nanocomposite alginate-Ca²⁺ hydrogel for melittin-assisted Ca²⁺-overload and photothermal cancer therapy

W. J. Yang, R. Ma, S. Wei, W. Sun, W. Xu and L. Wang, Chem. Commun., 2023, 59, 8568 DOI: 10.1039/D3CC01867A

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Chemical Communications