Issue 49, 2023
From the journal:

Chemical Communications

Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery†

Taichi Tsuneishi,a   Keiichi Kojima,ab   Fumika Kubota,c   Hideyoshi Harashima, ORCID logo c   Yuma Yamada ORCID logo c  and  Yuki Sudo ORCID logo *ab  

* Corresponding authors

a Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
E-mail: sudo@okayama-u.ac.jp

b Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

c Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

Abstract

Light-driven inward proton pump rhodopsin RmXeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a photoswitchable carrier utilized for intracellular substance delivery.

Graphical abstract: Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

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Article information

DOI
https://doi.org/10.1039/D3CC02056H
Article type
Communication
Submitted
28 Apr 2023
Accepted
23 May 2023
First published
23 May 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 7591-7594

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Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

T. Tsuneishi, K. Kojima, F. Kubota, H. Harashima, Y. Yamada and Y. Sudo, Chem. Commun., 2023, 59, 7591 DOI: 10.1039/D3CC02056H

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