Issue 48, 2023

Chloroacetyl boronate N-tosylhydrazone as a versatile synthetic building block

Abstract

Chloroacetyl boronate N-tosylhydrazone (CABT) has been synthesized as a reagent to generate a diverse range of molecular skeletons. CABT can undergo a series of transformations involving nucleophilic substitution of the chloride and coupling of the N-tosylhydrazones, followed by boryl group functionalization. We further demonstrated that this CABT reagent could enable a diversity-oriented synthesis.

Graphical abstract: Chloroacetyl boronate N-tosylhydrazone as a versatile synthetic building block

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2023
Accepted
22 May 2023
First published
23 May 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 7419-7422

Chloroacetyl boronate N-tosylhydrazone as a versatile synthetic building block

R. Miyazaki, K. Muto and J. Yamaguchi, Chem. Commun., 2023, 59, 7419 DOI: 10.1039/D3CC02086J

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