Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives

Abstract

Herein, we report the meta-C–H olefination of arylmethanesulfonates aided by a potentially versatile aliphatic nitrile-directing group under microwave irradiation conditions with fair to very good yields and good to outstanding regioselectivities. Significantly, the protocol showed broad substrate scope including olefin-derived drugs and cyclic olefins. Remarkably, a dual meta-C–H bond was amenable to generating the bis-olefination products.