Issue 66, 2023
From the journal:

Chemical Communications

Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry†

Mingxia Liu,abc   Jinjuan Xue,ad   Huwei Liu ORCID logo a  and  Yu Bai ORCID logo *a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
E-mail: yu.bai@pku.edu.cn

b Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China

c Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China

d State Key Laboratory of Toxicology and Medical Countermeasures, and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

Abstract

Novel imidazolium-based mass tags (IMTs) were designed, synthesized and applied to simultaneous in situ analysis of multiple biomarkers on less than 10 cells. The high sensitivity, flexible extensibility and excellent distinguishability of IMTs open new avenues for designing common mass tag templates suitable for mass spectrometric immunoassay and provide an ideal option for multiplex-sensitive detection at the cellular scale.

Graphical abstract: Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry

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Article information

DOI
https://doi.org/10.1039/D3CC02907G
Article type
Communication
Submitted
16 Jun 2023
Accepted
17 Jul 2023
First published
22 Jul 2023

Chem. Commun., 2023,59, 9996-9999

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Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry

M. Liu, J. Xue, H. Liu and Y. Bai, Chem. Commun., 2023, 59, 9996 DOI: 10.1039/D3CC02907G

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