Issue 85, 2023

β-Galactosidase-activated nitroxyl (HNO) donors provide insights into redox cross-talk in senescent cells

Abstract

The cross-talk among reductive and oxidative species (redox cross-talk), especially those derived from sulfur, nitrogen and oxygen, influence several physiological processes including aging. One major hallmark of aging is cellular senescence, which is associated with chronic systemic inflammation. Here, we report a chemical tool that generates nitoxyl (HNO) upon activation by β-galactosidase, an enzyme that is over-expressed in senescent cells. In a radiation-induced senescence model, the HNO donor suppressed reactive oxygen species (ROS) in a hydrogen sulfide (H2S)-dependent manner. Hence, the newly developed tool provides insights into redox cross-talk and establishes the foundation for new interventions that modulate levels of these species to mitigate oxidative stress and inflammation.

Graphical abstract: β-Galactosidase-activated nitroxyl (HNO) donors provide insights into redox cross-talk in senescent cells

Supplementary files

Article information

Article type
Communication
Submitted
27 Jun 2023
Accepted
29 Sep 2023
First published
09 Oct 2023

Chem. Commun., 2023,59, 12751-12754

Author version available

β-Galactosidase-activated nitroxyl (HNO) donors provide insights into redox cross-talk in senescent cells

L. R. Sawase, T. A. Kumar, A. B. Mathew, V. S. Khodade, J. P. Toscano, D. K. Saini and H. Chakrapani, Chem. Commun., 2023, 59, 12751 DOI: 10.1039/D3CC03094F

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