Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues

Kyangwi P. Malikidogo; Manon Isaac; Adrien Uguen; Sandra Même; Agnès Pallier; Rudy Clémençon; Jean-François Morfin; Sara Lacerda; Éva Tóth; Célia S. Bonnet

doi:10.1039/D3CC03137C

Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues†

‡^a Manon Isaac,^a Adrien Uguen,^a Sandra Même,^a Agnès Pallier,^a Rudy Clémençon,^a Jean-François Morfin,^a Sara Lacerda,

^a Éva Tóth

^a and Célia S. Bonnet

*^a

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* Corresponding authors

^a Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d’Orléans., Rue Charles Sadron, Orléans 45071, France
E-mail: celia.bonnet@cnrs.fr

Abstract

We present the in vitro characterisation of a Gd³⁺-based contrast agent that responds to Zn²⁺ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd³⁺-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.

Chemical Communications

Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues†

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Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues

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