Issue 83, 2023

Reprograming cancer cells by a BODIPY G-quadruplex stabiliser

Abstract

A cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1α, VIM, CDH1) related to metastasis is modulated. The stabiliser reprograms hypoxia-adaptive metabolism and an 1.82-fold increase in O2 consumption, enabling back-to-normal switching of energy metabolism, is observed. Stabilisers with a strong G-quadruplex affinity (0.38 μM Kd) significantly contribute to small molecule anti-cancer approaches.

Graphical abstract: Reprograming cancer cells by a BODIPY G-quadruplex stabiliser

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2023
Accepted
25 Sep 2023
First published
25 Sep 2023

Chem. Commun., 2023,59, 12447-12450

Reprograming cancer cells by a BODIPY G-quadruplex stabiliser

A. Baser, B. Basar, H. B. Dogan, G. Sener, N. G. Ozsamur, F. S. Celik, S. Altves and S. Erbas-Cakmak, Chem. Commun., 2023, 59, 12447 DOI: 10.1039/D3CC03453D

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