Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate

Abstract

Development of a new catalytic and straightforward strategy to construct C–N bonds is playing a pivotal role in synthetic chemistry. Here, we report a photocatalysed protocol to access direct C–H amidation of indoles, enabled by a rationally designed tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate. A series of biologically important aminoindoles were prepared under mild conditions with excellent regioselectivity and broad substrate scope.