NH4I-promoted electrosynthesis of 2-aminothiazole derivatives from ketone compounds and NH4SCN

Chaowei Zhang; Gaoqing Yuan

doi:10.1039/D3CC03547F

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NH₄I-promoted electrosynthesis of 2-aminothiazole derivatives from ketone compounds and NH₄SCN†

Chaowei Zhang^a and Gaoqing Yuan

*^a

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* Corresponding authors

^a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: gqyuan@scut.edu.cn

Abstract

A novel and efficient electrochemical synthesis of 2-aminothiazole derivatives from ketones and NH₄SCN is described. Under the co-action of NH₃ and iodine free radicals or iodine (I₂) electrochemically generated in situ, the target product 2-aminothiazole derivatives could be successfully obtained in good to excellent yields.

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Article information

DOI: https://doi.org/10.1039/D3CC03547F
Article type: Communication
Submitted: 25 Jul 2023
Accepted: 16 Sep 2023
First published: 18 Sep 2023

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Chem. Commun., 2023,59, 12188-12191

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NH₄I-promoted electrosynthesis of 2-aminothiazole derivatives from ketone compounds and NH₄SCN

C. Zhang and G. Yuan, Chem. Commun., 2023, 59, 12188 DOI: 10.1039/D3CC03547F

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Chemical Communications