Issue 42, 2023
From the journal:

CrystEngComm

Cocrystal formation by anti-solvent slurry†

Yi Li,a   Shun-Yu Li,a   Xia-Lin Dai,a   Tong-Bu Lu ORCID logo b  and  Jia-Mei Chen ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China
E-mail: chenjiamei@email.tjut.edu.cn

b Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China

Abstract

An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces solubility of reactants and products, and levels out solubility difference of reactants, and consequently generates cocrystals with a higher success rate, higher purity and higher yield than commonly used slurry methods.

Graphical abstract: Cocrystal formation by anti-solvent slurry

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Article information

DOI
https://doi.org/10.1039/D3CE00486D
Article type
Communication
Submitted
10 May 2023
Accepted
25 Jun 2023
First published
16 Oct 2023

CrystEngComm, 2023,25, 5882-5886

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Cocrystal formation by anti-solvent slurry

Y. Li, S. Li, X. Dai, T. Lu and J. Chen, CrystEngComm, 2023, 25, 5882 DOI: 10.1039/D3CE00486D

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