A linear CH+–NO3− base pair motif promoted by AgNO3 mediated proton transfer between guanosine and cytidine

Qiong Wu; Yingying Chai; Ridong Huang; Hai Chen; Yang He

doi:10.1039/D3CE00916E

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A linear CH⁺–NO₃⁻ base pair motif promoted by AgNO₃ mediated proton transfer between guanosine and cytidine†

Qiong Wu,‡^abc Yingying Chai,‡^abc Ridong Huang,‡^abc Hai Chen^abc and Yang He

*^abc

Author affiliations

* Corresponding authors

^a Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
E-mail: heyangqx@scu.edu.cn

^b Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China

^c Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China

Abstract

Metallo-base pairs are of immense interest. However, uncertainties remain regarding Ag⁺–nucleic acid component interactions. Instead of a coordinated polymer [C–Ag][NO₃] (1) embedded with Ag⁺ nanowires in an aqueous C/AgNO₃ system, a novel base paired ionic crystal CH⁺–NO₃⁻ (2) was formed in a complex hydrogel system comprising guanosine (G), cytidine (C) and AgNO₃. The static structural characteristics and underlying coupled reaction mechanisms driving the proton transfer between the G and C in this multi-component system were characterized. This information will be valuable in the context of bio-inorganic chemistry involving G- and C-rich genomic sequences.

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Article information

DOI: https://doi.org/10.1039/D3CE00916E
Article type: Paper
Submitted: 15 Sep 2023
Accepted: 31 Oct 2023
First published: 01 Nov 2023

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CrystEngComm, 2023,25, 6549-6555

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A linear CH⁺–NO₃⁻ base pair motif promoted by AgNO₃ mediated proton transfer between guanosine and cytidine

Q. Wu, Y. Chai, R. Huang, H. Chen and Y. He, CrystEngComm, 2023, 25, 6549 DOI: 10.1039/D3CE00916E

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