Issue 3, 2023

Small-molecule fluorogenic probes for mitochondrial nanoscale imaging

Abstract

Mitochondria are inextricably linked to the development of diseases and cell metabolism disorders. Super-resolution imaging (SRI) is crucial in enhancing our understanding of mitochondrial ultrafine structures and functions. In addition to high-precision instruments, super-resolution microscopy relies heavily on fluorescent materials with unique photophysical properties. Small-molecule fluorogenic probes (SMFPs) have excellent properties that make them ideal for mitochondrial SRI. This paper summarizes recent advances in the field of SMFPs, with a focus on the chemical and spectroscopic properties required for mitochondrial SRI. Finally, we discuss future challenges in this field, including the design principles of SMFPs and nanoscopic techniques.

Graphical abstract: Small-molecule fluorogenic probes for mitochondrial nanoscale imaging

Article information

Article type
Review Article
Submitted
19 Sep 2022
First published
14 Dec 2022

Chem. Soc. Rev., 2023,52, 942-972

Small-molecule fluorogenic probes for mitochondrial nanoscale imaging

R. Zhai, B. Fang, Y. Lai, B. Peng, H. Bai, X. Liu, L. Li and W. Huang, Chem. Soc. Rev., 2023, 52, 942 DOI: 10.1039/D2CS00562J

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