Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry

Gabriella Tito; Romualdo Troisi; Giarita Ferraro; Andrea Geri; Lara Massai; Luigi Messori; Filomena Sica; Antonello Merlino

doi:10.1039/D3DT00320E

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Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry†

Gabriella Tito,

^a Romualdo Troisi,

^a Giarita Ferraro,

^a Andrea Geri,^b Lara Massai,

^b Luigi Messori,

^b Filomena Sica

^a and Antonello Merlino

*^a

Author affiliations

* Corresponding authors

^a Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo via Cintia, I-80126 Napoli, Italy
E-mail: antonello.merlino@unina.it

^b Department of Chemistry “U. Schiff”, University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Italy

Abstract

The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine via axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion.

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Article information

DOI: https://doi.org/10.1039/D3DT00320E
Article type: Communication
Submitted: 01 Feb 2023
Accepted: 05 May 2023
First published: 09 May 2023
This article is Open Access

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Dalton Trans., 2023,52, 6992-6996

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Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry

G. Tito, R. Troisi, G. Ferraro, A. Geri, L. Massai, L. Messori, F. Sica and A. Merlino, Dalton Trans., 2023, 52, 6992 DOI: 10.1039/D3DT00320E

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Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry†

Abstract

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Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry

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