Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

Alicia Marco; Gloria Vigueras; Natalia Busto; Natalia Cutillas; Delia Bautista; José Ruiz

doi:10.1039/D3DT01678A

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Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria†

Alicia Marco,

‡^a Gloria Vigueras,

‡^a Natalia Busto,

*^bc Natalia Cutillas,^a Delia Bautista^d and José Ruiz

*^a

Author affiliations

* Corresponding authors

^a Departamento de Química Inorgánica, Universidad de Murcia, and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30100 Murcia, Spain
E-mail: jruiz@um.es

^b Departamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, Burgos, Spain
E-mail: nbusto@ubu.es

^c Departamento de Ciencias de la Salud. Facultad de Ciencias de la Salud. Universidad de Burgos, Hospital Militar, Paseo de los Comendadores, s/n, 09001 Burgos, Spain

^d SUIC-ACTI, Universidad de Murcia, E-30100 Murcia, Spain

Abstract

New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to switch on the antibacterial activity of the complexes towards Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.

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DOI: https://doi.org/10.1039/D3DT01678A
Article type: Communication
Submitted: 01 Jun 2023
Accepted: 18 Jun 2023
First published: 20 Jun 2023
This article is Open Access

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Dalton Trans., 2023,52, 13482-13486

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Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

A. Marco, G. Vigueras, N. Busto, N. Cutillas, D. Bautista and J. Ruiz, Dalton Trans., 2023, 52, 13482 DOI: 10.1039/D3DT01678A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Dalton Transactions

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria†

Abstract

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Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

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