Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

Na Yang; Anni Li; Hui Gao; Li-Mei Liao; Yu-Ping Yang; Pei-Long Wang; Hongji Li

doi:10.1039/D2GC04782A

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Electrochemical oxidation-induced benzylic C(sp³)–H functionalization towards the atom-economic synthesis of oxazole heterocycles†

Na Yang,^a Anni Li,^a Hui Gao,

^ac Li-Mei Liao,^a Yu-Ping Yang,^a Pei-Long Wang

*^ab and Hongji Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China
E-mail: wangpl@chnu.edu.cn, hongjili@chnu.edu.cn

^b Information College, Huaibei Normal University, Huaibei 235000, China

^c Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China

Abstract

A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence of any catalyst or external oxidant. This electrochemical reaction features high atom economy and mild conditions, affording oxazole derivatives in moderate to good yields.

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Article information

DOI: https://doi.org/10.1039/D2GC04782A
Article type: Paper
Submitted: 15 Dec 2022
Accepted: 23 May 2023
First published: 24 May 2023

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Green Chem., 2023,25, 5128-5133

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Electrochemical oxidation-induced benzylic C(sp³)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

N. Yang, A. Li, H. Gao, L. Liao, Y. Yang, P. Wang and H. Li, Green Chem., 2023, 25, 5128 DOI: 10.1039/D2GC04782A

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