EtOH-catalyzed electrosynthesis of imidazolidine-fused sulfamidates from N-sulfonyl ketimines, N-arylglycines and formaldehyde

Abstract

With formaldehyde as an atom-economical carbonyl synthon, the EtOH-catalyzed electrochemical multicomponent synthesis of various imidazolidine-fused sulfamidates was developed. A wide range of products were obtained in good to excellent yields under organic oxidant-free, energy-saving and mild conditions. The mechanistic study revealed that the in situ generated ethoxide played a crucial role in producing aminomethylene radicals at a lower voltage.