Issue 8, 2023

Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source

Abstract

An environmentally benign electrochemical approach has been developed for the α-hydroxymethylation of ketones using N,N-dimethylformamide as the carbon source for the construction of β-hydroxy ketones. This method does not require metal catalysts or chemical oxidants and proceeded smoothly at room temperature to demonstrate tolerance of a broad range of functional groups.

Graphical abstract: Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source

Supplementary files

Article information

Article type
Communication
Submitted
12 Jan 2023
Accepted
21 Mar 2023
First published
22 Mar 2023

Green Chem., 2023,25, 3016-3020

Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source

J. Zheng, Y. Li, Y. Pan, X. Hu, X. Ye and R. Li, Green Chem., 2023, 25, 3016 DOI: 10.1039/D3GC00144J

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