Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Jeffrey T. Borenstein; Gerard Cummins; Abhishek Dutta; Eyad Hamad; Michael Pycraft Hughes; Xingyu Jiang; Hyowon (Hugh) Lee; Kin Fong Lei; Xiaowu (Shirley) Tang; Yuanjin Zheng; Jie Chen

doi:10.1039/D3LC00296A

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Jeffrey T. Borenstein,

^a Gerard Cummins,

^b Abhishek Dutta,^c Eyad Hamad,

^d Michael Pycraft Hughes,

^e Xingyu Jiang,

^f Hyowon (Hugh) Lee,

^g Kin Fong Lei,

^h Xiaowu (Shirley) Tang,

ⁱ Yuanjin Zheng^j and Jie Chen

*^k

Author affiliations

* Corresponding authors

^a Bioengineering Division, Draper, Cambridge MA 02139, USA
E-mail: jborenstein@draper.com

^b School of Engineering, University of Birmingham, Edgbaston, UK
E-mail: G.Cummins@bham.ac.uk

^c Department of Electrical & Computer Engineering, University of Connecticut, USA
E-mail: abhishek.dutta@uconn.edu

^d Biomedical Engineering Department, School of Applied Medical Sciences, German Jordanian University, Amman, Jordan
E-mail: Eyad.Hamad@gju.edu.jo

^e Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates
E-mail: Michael.hughes@ku.ac.ae

^f Department of Biomedical Engineering, Southern University of Science and Technology, China
E-mail: jiang@sustech.edu.cn

^g Weldon School of Biomedical Engineering, Center for Implantable Devices, Purdue University, West Lafayette, IN, USA
E-mail: hwlee@purdue.edu

^h Chang Gung University, Taiwan
E-mail: kflei@mail.cgu.edu.tw

ⁱ University of Waterloo, Waterloo, ON N2L 3G1, Canada
E-mail: tangxw@uwaterloo.ca

^j Nanyang Technological University, Singapore
E-mail: YJZHENG@ntu.edu.sg

^k Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB T6G 2R3, Canada
E-mail: jchen@ece.ualberta.ca

Abstract

The development of micro- and nanotechnology for biomedical applications has defined the cutting edge of medical technology for over three decades, as advancements in fabrication technology developed originally in the semiconductor industry have been applied to solving ever-more complex problems in medicine and biology. These technologies are ideally suited to interfacing with life sciences, since they are on the scale lengths as cells (microns) and biomacromolecules (nanometers). In this paper, we review the state of the art in bionanotechnology and bioMEMS (collectively BNM), including developments and challenges in the areas of BNM, such as microfluidic organ-on-chip devices, oral drug delivery, emerging technologies for managing infectious diseases, 3D printed microfluidic devices, AC electrokinetics, flexible MEMS devices, implantable microdevices, paper-based microfluidic platforms for cellular analysis, and wearable sensors for point-of-care testing.

Lab on a Chip

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Abstract

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Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

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