Issue 12, 2023

Hydrosilylative reduction of secondary amides to amines catalyzed by geometry-constrained NNN-cobalt complexes

Abstract

Reported herein is a well-defined geometry-constrained tridentate NNN-cobalt complex for the hydrosilylative reduction of secondary amides with the low-cost PMHS as the hydride donor reductant. In this catalytic protocol, a wide range of secondary amides, including benzamide-type and aliphatic carboxylic acid-derived secondary amides, served as suitable substrates to afford their corresponding secondary amines in moderate to excellent yields. The scaled-up reaction strongly demonstrated the practicality and efficiency of the developed method.

Graphical abstract: Hydrosilylative reduction of secondary amides to amines catalyzed by geometry-constrained NNN-cobalt complexes

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2023
Accepted
09 Feb 2023
First published
10 Feb 2023

New J. Chem., 2023,47, 5603-5610

Hydrosilylative reduction of secondary amides to amines catalyzed by geometry-constrained NNN-cobalt complexes

S. Dong, Z. Zong, N. Sun, B. Hu, Z. Shen, X. Hu and L. Jin, New J. Chem., 2023, 47, 5603 DOI: 10.1039/D3NJ00372H

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