Copper-promoted indirect trifluoromethylthiolation of sulfuryl chloride with TMSCF3: facile access to trifluoromethyl thioethers

Abstract

A simple and practical synthetic method for trifluoromethyl thioethers through copper-promoted indirect trifluoromethylthiolation has been developed. The reaction of sulfuryl chloride with commercial Ruppert–Prakash reagent TMSCF3 is performed under mild reaction conditions. This transformation efficiently affords various aryl or alkyl sulfuryl trifluoromethyl thioethers with mild reaction conditions, wide substrate scope and excellent compatibility.