Highly diastereoselective Heck–Matsuda reaction with pyrazolyl diazonium salts

Abstract

The Heck–Matsuda (HM) reaction is a powerful synthetic approach cut out for C–C bonds formation under mild conditions. We demonstrated that pyrazolyl diazonium salts are suitable reagents in this protocol, allowing us to deliver highly substituted cyclopentenols and cyclopentenamines with an excellent degree of diastereoselectivity and a control of enantioselectivity.