Issue 12, 2023

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

Abstract

Covering: 2011–2022

The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production via enzymatic fusions and scaffolds, or subcellular compartmentalization.

Graphical abstract: Engineering yeast for the production of plant terpenoids using synthetic biology approaches

Supplementary files

Article information

Article type
Review Article
Submitted
25 Jan 2023
First published
31 Jul 2023
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2023,40, 1822-1848

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

J. Bureau, M. E. Oliva, Y. Dong and C. Ignea, Nat. Prod. Rep., 2023, 40, 1822 DOI: 10.1039/D3NP00005B

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