Issue 7, 2023

Non-directed C–H arylation of electron-deficient arenes by synergistic silver and Pd3 cluster catalysis

Abstract

Transition-metal clusters have attracted great attention in catalysis due to their unique reactivity and electronic properties, especially for novel substrate binding and activation modes at the bridging coordination sites of metal clusters. Although palladium complexes have demonstrated outstanding catalytic performance in various transformations, the catalytic behaviors of polynuclear palladium clusters in many important synthetic methodologies remain much less explored so far. Herein, we disclose the use of an atomically defined tri-nuclear palladium (Pd3Cl) species as a catalyst precursor in Ag(I)-assisted direct C–H arylation with aryl iodides under mild conditions. This catalyst system leads to the formation of synthetically important biaryls in good yields with high site selectivities without the assistance of directing groups.

Graphical abstract: Non-directed C–H arylation of electron-deficient arenes by synergistic silver and Pd3 cluster catalysis

Supplementary files

Article information

Article type
Paper
Submitted
20 Oct 2022
Accepted
09 Jan 2023
First published
10 Jan 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 3560-3565

Non-directed C–H arylation of electron-deficient arenes by synergistic silver and Pd3 cluster catalysis

J. Yao, J. Bai, X. Kang, M. Zhu, Y. Guo and X. Wang, Nanoscale, 2023, 15, 3560 DOI: 10.1039/D2NR05825A

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