Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Miguel M. Lino; Tiago Rondão; Arnab Banerjee; Inês Aires; Magda Rodrigues; Tiago Reis; António Santinha; Dominique Fernandes; Débora Serrenho; Tomás Sobrino; João Sargento-Freitas; Frederico C. Pereira; Ana Luísa Carvalho; Lino Ferreira

doi:10.1039/D3NR03861K

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model†

Miguel M. Lino,^a Tiago Rondão,

^a Arnab Banerjee,^a Inês Aires,^a Magda Rodrigues,^a Tiago Reis,^a António Santinha,^a Dominique Fernandes,^a Débora Serrenho,

^ab Tomás Sobrino,^c João Sargento-Freitas,^d Frederico C. Pereira,^def Ana Luísa Carvalho^ag and Lino Ferreira

*^ad

Author affiliations

* Corresponding authors

^a CNC – Centre for Neuroscience and Cell Biology, CIBB – Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal
E-mail: lino.ferreira@uc.pt

^b PhD Programme in Experimental Biology and Biomedicine, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Portugal

^c NeuroAging Laboratory (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

^d Faculty of Medicine, University of Coimbra, Coimbra, Portugal

^e iCBR, Coimbra Institute for Clinical and Biomedical Research, CIBB – Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal

^f Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Portugal

^g Department of Life Sciences, University of Coimbra, Coimbra, Portugal

Abstract

Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain. sEVs from mononuclear cells (MNCs) showed superior effects in vitro to sEVs from mesenchymal stem cells (MSCs) and were able to promote neuroprotection and decrease microglia reactivity in a stroke mouse model.

Nanoscale

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model†

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Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

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