A racemic approach towards the synthesis of the ABC (7/7/5) ring system of Schisandra triterpenoid kadlongilactones is described. The synthesis features two key transformations: (1) conjugate addition followed by iodolactonization to build the cis-fused 7/7 ring; and (2) conjugate addition–Rubottom oxidation cascade followed by ring-closing metathesis to construct the 7/7/5 tricyclic ring.
L. Li, P. Li, T. Li, M. Zhang, W. Liu, J. Li, L. Wang and Y. Chen, Org. Biomol. Chem., 2023, 21, 1704 DOI: 10.1039/D2OB01701F
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