Issue 1, 2023

Palladium-catalyzed C(sp3)–H nitrooxylation of masked alcohols

Abstract

A palladium-catalyzed β-C(sp3)–H nitrooxylation of aliphatic alcohols with AgNO2 is reported. An 8-formylquinoline-derived oxime is installed as an exo-type directing group for sp3 C–H activation and selectfluor acts as the oxidant. The reaction tolerates a variety of functional groups and shows good selectivity for β-C–H nitrooxylation of alcohols.

Graphical abstract: Palladium-catalyzed C(sp3)–H nitrooxylation of masked alcohols

Supplementary files

Article information

Article type
Communication
Submitted
20 Oct 2022
Accepted
24 Nov 2022
First published
25 Nov 2022

Org. Biomol. Chem., 2023,21, 75-79

Palladium-catalyzed C(sp3)–H nitrooxylation of masked alcohols

Y. Xue, R. Zhou, J. Luo, B. Hu, Z. Liu and C. Jiang, Org. Biomol. Chem., 2023, 21, 75 DOI: 10.1039/D2OB01919A

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