Issue 7, 2023
From the journal:

Organic & Biomolecular Chemistry

Iridium-catalysed thioether-directed regioselective cycloaddition of internal alkynes with azides†

Peng Ye, ORCID logo a   Huan-Le Li,a   Jun Pu,a   Lei Chen,a   Shuang Wang,a   Zhen-Yuan Xu,a   Shao-Jie Lou ORCID logo *a  and  Dan-Qian Xu ORCID logo *a  

* Corresponding authors

a Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: chrc@zjut.edu.cn, loushaojie@zjut.edu.cn

Abstract

We report herein a cationic iridium-catalysed thioether-directed alkyne–azide cycloaddition reaction. Diverse 2-alkynyl phenyl sulfides can undergo cycloaddition with different azides in a regioselective fashion. The reaction features high efficiency, a short reaction time, and a broad substrate scope, providing modular access to complex S-containing triazoles.

Graphical abstract: Iridium-catalysed thioether-directed regioselective cycloaddition of internal alkynes with azides

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Article information

DOI
https://doi.org/10.1039/D2OB02082C
Article type
Communication
Submitted
14 Nov 2022
Accepted
11 Jan 2023
First published
12 Jan 2023

Org. Biomol. Chem., 2023,21, 1389-1394

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Iridium-catalysed thioether-directed regioselective cycloaddition of internal alkynes with azides

P. Ye, H. Li, J. Pu, L. Chen, S. Wang, Z. Xu, S. Lou and D. Xu, Org. Biomol. Chem., 2023, 21, 1389 DOI: 10.1039/D2OB02082C

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