Issue 12, 2023

Rh(iii)-catalyzed (5 + 2)-cycloaddition reactions of ortho-hydroxyethyl phenols with internal alkynes: efficient synthesis of benzoxepines

Abstract

An unprecedented (5 + 2)-cycloaddition reaction of ortho-hydroxyethyl phenol and internal alkyne was developed. This Rh(III)-catalyzed reaction provided benzoxepine derivatives which have very high biological significance. A wide range of ortho-hydroxyethyl phenols and internal alkynes were studied to provide the benzoxepines in high yields.

Graphical abstract: Rh(iii)-catalyzed (5 + 2)-cycloaddition reactions of ortho-hydroxyethyl phenols with internal alkynes: efficient synthesis of benzoxepines

Supplementary files

Article information

Article type
Paper
Submitted
03 Feb 2023
Accepted
28 Feb 2023
First published
01 Mar 2023

Org. Biomol. Chem., 2023,21, 2516-2523

Rh(III)-catalyzed (5 + 2)-cycloaddition reactions of ortho-hydroxyethyl phenols with internal alkynes: efficient synthesis of benzoxepines

P. Bhorali, J. Phukon and S. Gogoi, Org. Biomol. Chem., 2023, 21, 2516 DOI: 10.1039/D3OB00170A

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