Synthesis of 2-carboxyaniline-substituted maleimides from 2′-nitrochalcones†
Nicolai A.
Aksenov, 
*a
Dmitrii A.
Aksenov,
a
Daniil D.
Ganusenko,
a
Igor A.
Kurenkov,
a
Alexander V.
Leontiev
a
and
Alexander V.
Aksenov
a
*a
Dmitrii A.
Aksenov,
a
Daniil D.
Ganusenko,
a
Igor A.
Kurenkov,
a
Alexander V.
Leontiev
a
and
Alexander V.
Aksenov
a
Abstract
A practical, one-pot approach to 3-anilino-4-(het)arylmaleimides by simple heating of aqueous DMSO solution of 2′-nitrochalcones with potassium cyanide in the presence of formic acid has been developed. This new reaction provides effective access to a variety of β-substituted α-aminomaleimides which have recently become a subject of growing interest as small, easily modified and environmentally responsive fluorescent probes.
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