Catalytic asymmetric CO2 utilization reaction for the enantioselective synthesis of chiral 2-oxazolidinones

Abstract

Catalytic asymmetric bromocyclizations of in situ generated carbamic acids from CO₂ and allylamines were achieved via the use of a BINOL-derived chiral bifunctional selenide catalyst bearing a hydroxy group. Chiral 2-oxazolidinone products as important pharmaceutical building blocks were obtained with good enantioselectivities by the present catalytic asymmetric CO₂ utilization reactions.