Issue 38, 2023

Synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes by cross-coupling induced by transition metals – formation of C–C bonds

Abstract

The synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs), by forming a C–C bond, can be achieved by cross-coupling reactions using transition metal catalysts. Two main strategies are described to access these 1,3-disubstituted BCPs, either from nucleophilic BCPs or electrophilic BCPs. Mechanisms are included where relevant.

Graphical abstract: Synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes by cross-coupling induced by transition metals – formation of C–C bonds

Article information

Article type
Review Article
Submitted
29 Jun 2023
Accepted
02 Sep 2023
First published
13 Sep 2023

Org. Biomol. Chem., 2023,21, 7666-7680

Synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes by cross-coupling induced by transition metals – formation of C–C bonds

T. Yasukawa, K. S. Håheim and J. Cossy, Org. Biomol. Chem., 2023, 21, 7666 DOI: 10.1039/D3OB01036H

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