An unnatural amino acid modified human insulin derivative for visual monitoring of insulin aggregation†
Abstract
Insulin often forms toxic fibrils during production and transportation, which are deposited as amyloids at repeated injection sites in diabetic patients. Distinguishing early fibrils from non-fibrillated insulin is difficult. Herein, we introduce a chemically modified human insulin derivative with a distinct visual colour transition upon aggregation, facilitating insulin quality assessment.
- This article is part of the themed collection: Celebrating 175 years of IIT Roorkee