Issue 37, 2023

An unnatural amino acid modified human insulin derivative for visual monitoring of insulin aggregation

Abstract

Insulin often forms toxic fibrils during production and transportation, which are deposited as amyloids at repeated injection sites in diabetic patients. Distinguishing early fibrils from non-fibrillated insulin is difficult. Herein, we introduce a chemically modified human insulin derivative with a distinct visual colour transition upon aggregation, facilitating insulin quality assessment.

Graphical abstract: An unnatural amino acid modified human insulin derivative for visual monitoring of insulin aggregation

Supplementary files

Article information

Article type
Paper
Submitted
29 Jun 2023
Accepted
25 Aug 2023
First published
28 Aug 2023

Org. Biomol. Chem., 2023,21, 7561-7566

An unnatural amino acid modified human insulin derivative for visual monitoring of insulin aggregation

S. Sen, R. Ali, H. Singh, A. Onkar, P. Bhadauriya, S. Ganesh and S. Verma, Org. Biomol. Chem., 2023, 21, 7561 DOI: 10.1039/D3OB01038D

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