Issue 43, 2023

Photochemical acridone-mediated direct arylation of (hetero)arenes with aryl diazonium salts

Abstract

A metal-free photochemical C–H direct arylation using acridone as a photoredox catalyst to facilitate the reaction is described. Diazonium salts as precursors for aryl radicals, demonstrated by a fluorescence quenching experiment and free radical trapping experiment, allow the functionalization of (hetero)arenes under mild conditions. A series of valuable substituted biaryl and aryl-heteroaryl compounds were prepared in moderate to good yields via the coupling. Moreover, this methodology is shown to be applicable to scale-up synthesis.

Graphical abstract: Photochemical acridone-mediated direct arylation of (hetero)arenes with aryl diazonium salts

Supplementary files

Article information

Article type
Paper
Submitted
31 Aug 2023
Accepted
06 Oct 2023
First published
24 Oct 2023

Org. Biomol. Chem., 2023,21, 8739-8743

Photochemical acridone-mediated direct arylation of (hetero)arenes with aryl diazonium salts

Z. Li, L. Chen, D. Rong, L. Yuan and Y. Xie, Org. Biomol. Chem., 2023, 21, 8739 DOI: 10.1039/D3OB01389H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements