B(C6F5)3-catalyzed hydrogermylation of enones: a facile route to germacycles

Jiangkun Xiong; Maying Yan; Lvnan Jin; Weihong Song; Lei Xiao; Dong Xu; Chunyang Zhai; Douglas W. Stephan; Jing Guo

doi:10.1039/D3OB01402A

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B(C₆F₅)₃-catalyzed hydrogermylation of enones: a facile route to germacycles†

Jiangkun Xiong,‡^ab Maying Yan,‡^a Lvnan Jin,

^a Weihong Song,^a Lei Xiao,^a Dong Xu,^a Chunyang Zhai,*^b Douglas W. Stephan

*^ac and Jing Guo

*^a

Author affiliations

* Corresponding authors

^a Institute of Drug Discovery Technology, Ningbo University, Zhejiang, China
E-mail: guojing@nbu.edu.cn

^b School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China
E-mail: zhaichunyang@nbu.edu.cn

^c Department of Chemistry, University of Toronto, Toronto, 80 St. George Street, Ontario M5S 3H6, Canada
E-mail: dstephan@chem.utoronto.ca

Abstract

Organogermacycles are important skeletons for medicinal chemistry and materials. Herein, we reported a B(C₆F₅)₃ mediated domino hydrogermylation reaction of enones with dihydrogermanes, affording 21 variants of organogermacycle compounds. These germacyclic compounds were obtained in good to excellent yields (up to 99% yield) under mild reaction conditions.

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Article information

DOI: https://doi.org/10.1039/D3OB01402A
Article type: Communication
Submitted: 02 Sep 2023
Accepted: 30 Sep 2023
First published: 02 Oct 2023

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Org. Biomol. Chem., 2023,21, 8098-8101

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B(C₆F₅)₃-catalyzed hydrogermylation of enones: a facile route to germacycles

J. Xiong, M. Yan, L. Jin, W. Song, L. Xiao, D. Xu, C. Zhai, D. W. Stephan and J. Guo, Org. Biomol. Chem., 2023, 21, 8098 DOI: 10.1039/D3OB01402A

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Organic & Biomolecular Chemistry