Issue 5, 2023

A light-operated dual-mode method for neuroblastoma diagnosis based on a Tb-MOF: from biometabolite detection to logic devices

Abstract

Exploring simple analytical techniques with high accuracy and reliability to quantify biomolecules is crucial, but it remains a great challenge for disease diagnosis. Since the body fluid concentration of most biological targets usually varies in a rather limited range between normal and pathological states, and most systems are greatly limited by a single mechanism/mode of detection, which makes them susceptible to false positive/negative results. Herein, we successfully synthesized a double-mechanism-driven fluorescent sensor based on a Tb-based metal–organic framework (Tb-DBA), which performs quantitative recognition of urinary vanillylmandelic acid (VMA) as an early pathological signature of neuroblastoma (NEURO) accompanied by two completely different luminescence phenomena in a smaller concentration window by switching the excitation wavelength. Notably, Tb-DBA shows high sensitivity, great selectivity, and low detection limit toward epinephrine (EP, the metabolic precursor of VMA). The bifunctional detector based on Tb-DBA inherently improves analytical reliability and greatly reduces the chance of false negatives/positives for NEURO diagnosis. In addition, a one-to-two logic gate based on the interaction between Tb-DBA and VMA was constructed for the analysis of VMA level, which can be further used for NEURO diagnosis. This work represents the first example to design a luminescent sensor coupled with multiple mechanisms in a single sensing platform for the diagnosis of NEURO, providing a new avenue for the clinical application of two-dimensional detection biomarkers for accurate diagnosis in serious diseases.

Graphical abstract: A light-operated dual-mode method for neuroblastoma diagnosis based on a Tb-MOF: from biometabolite detection to logic devices

Supplementary files

Article information

Article type
Research Article
Submitted
21 Dec 2022
Accepted
06 Feb 2023
First published
07 Feb 2023

Inorg. Chem. Front., 2023,10, 1660-1670

A light-operated dual-mode method for neuroblastoma diagnosis based on a Tb-MOF: from biometabolite detection to logic devices

Y. Liu, W. Dan and B. Yan, Inorg. Chem. Front., 2023, 10, 1660 DOI: 10.1039/D2QI02701A

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