Issue 12, 2023

A novel photoswitchable AIE-active supramolecular photosensitizer with synergistic enhancement of ROS-generation ability constructed by a two-step sequential FRET process

Abstract

Photosensitizers (PSs), featuring switchable properties to achieve tunable reactive oxygen species (ROS) generation, are highly desirable in photodynamic treatment and antibacterial applications. A supramolecular strategy combined with aggregation-induced emission (AIE) characteristics for synergistic design of an effective PS has emerged as a promising approach to reduce its side effects. Herein, we have constructed a ternary supramolecular PS based on a two-step Förster resonance energy transfer (FRET) process using an AIE-active pillar[5]arene host, a spiropyran derivative (SP-G) guest, and Nile blue (NiB) dye in aqueous media. The reversible isomerization process of SP-G endows this PS with the “on–off” switchability. Under UV light irradiation, the guest SP-G (non-emissive closed-form) can be converted to merocyanine MC-G (emissive open-form). And the in situ formed MC-G can function as the first energy acceptor and an efficient PS for ROS generation. Meanwhile, the introduction of NiB promotes a synergistic ROS-generation activity, leading to a two-step dynamic FRET process in response to UV and visible light irradiation. Moreover, this photoswitchable system with excellent controllable fluorescence performance and ROS-generation ability can be applied to inactivation of cancer cells and bacteria. The present work on the basis of a supramolecular strategy provides a proof-of-concept and new insight for the fabrication of smart PS materials.

Graphical abstract: A novel photoswitchable AIE-active supramolecular photosensitizer with synergistic enhancement of ROS-generation ability constructed by a two-step sequential FRET process

Supplementary files

Article information

Article type
Research Article
Submitted
15 Feb 2023
Accepted
23 Mar 2023
First published
24 Mar 2023

Mater. Chem. Front., 2023,7, 2484-2492

A novel photoswitchable AIE-active supramolecular photosensitizer with synergistic enhancement of ROS-generation ability constructed by a two-step sequential FRET process

X. Tian, S. Li, K. Velmurugan, Z. Bai, Q. Liu, K. Wang, M. Zuo and X. Hu, Mater. Chem. Front., 2023, 7, 2484 DOI: 10.1039/D3QM00153A

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