Issue 3, 2023

Palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4H)-ones: synthesis of piperidine-2,6-dione derivatives

Abstract

A palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4H)-ones proceeded smoothly under mild reaction conditions to give various piperidine derivatives in moderate to excellent yields. The reaction worked via aza-1,4-dipole from in situ deprotonation of amido-tethered allyl carbonates.

Graphical abstract: Palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4H)-ones: synthesis of piperidine-2,6-dione derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
08 Nov 2022
Accepted
09 Dec 2022
First published
10 Dec 2022

Org. Chem. Front., 2023,10, 813-818

Palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4H)-ones: synthesis of piperidine-2,6-dione derivatives

L. Wang, M. Liu, M. Lu, B. Wang, Q. Han, J. Jin, S. Yu, Y. Wu and H. Guo, Org. Chem. Front., 2023, 10, 813 DOI: 10.1039/D2QO01783K

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